Upon his return to Italy, Uguccione studied law at Rome University for the 1924-1925 academic year and within the next four years, completed a second degree in Political Science. He practiced law after graduation, but found it unfulfilling. After realizing he did not want to be a lawyer, Uguccione decided to pursue his literary interests. In 1930 he moved to the United States where he was offered a teaching position in the Italian department at Yale University. Uguccione pursued his passion for education and writing by working for two literary organizations, the Italy-America Review and the Corriere d’America, in New York. In these magazines, Uguccione wrote articles concerning Italy’s artistic wealth, natural beauty, and recent achievements of the Italian regime. He would remain in the United States until 1936, establishing himself as a published and well-recognized writer. Uguccione decided to leave America as he no longer received financial help from his family and his salary at Yale was not enough to support him.
